Men are more likely to develop Covid-19 and die more often than women. Researchers are looking for possible explanations for this.
In Germany, around 56 percent of the people who died of Covid-19 are male. It is 64 percent in China and 71 percent in Italy.
No more men are infected with SARS-CoV-2 than women. A Study from China tried to clarify why more men than women die from COVID-19 infection.
Option 1: Men are more susceptible due to a special receptor
The researchers’ first vague assumption is that men may have a healthier lifestyle than women, making them less healthy and more susceptible to disease.
Another possible reason could be a receptor that researchers found in the blood of men in higher numbers than in women.
To the ACE2 receptor docks SARS-CoV-2 to get into a human cell. The researchers suspect that someone who has many ACE2 receptors is more likely to develop Covid-19.
Option 2: Estrogen helps fight disease
In previous pandemics such as SARS and MERS, more men than women became seriously ill. Doctors researched the phenomenon after the SARS pandemic of 2002/2003 with mice. In the study, female mice died less frequently from SARS than males. That changed, however, when the researchers began producing hormones in females estrogen undermined.
So the female sex hormone could play a role in fighting a virus. In Vaccine, studies could e.g. it has been shown that women develop antibodies more quickly and more than men.
3rd possibility: women have a genetic advantage
There is another factor that favors women. On the X chromosome, there are some important genes that regulate the immune system. Women have two X chromosomes, while men have one X and one Y chromosome.
Female immune cells can, therefore, use the genes of two X chromosomes. You may be able to identify and fight pathogens more quickly.
Evolutionarily this could have been an advantage for mankind. After all, the female body must be able to protect an unborn baby from harmful influences as much as possible.
So far, however, there is no clear answer to the question of why men die of Covid-19 more often than women.